Curr Biol：分散注意力可有效减轻疼痛感

近日，刊登在国际著名杂志Cell的子刊Current Biology上的一篇数据分析报告指出，并用心理干扰（分心）的步骤可以使得痛楚加大，然而这种痛楚减缓加大的现象并不表现在腹部。这项数据分析推断出是基于用作成像的骨髓机能性磁共振成像关键技术（fMRI关键技术），对人们由于零下引起的痛楚水平进行数据分析，数据分析了解到，心理干扰确实可以在中所枢痛楚处理早期抑制痛楚接收机的起源于。来自汉堡-埃彭基尔大学医学院的历史学者Christian Sprenger指出，这种现象并不仅仅是一种心理现象，而是一种热衷的神经机制，可以降更高从神经上升至神经高级区域内的痛楚接收机。

这种现象涉及到了介导的类物质，这种物质产生自神经，在加大痛楚的流程中所扮演着不可忽视女角。数据分析人员让与才会者分别完成一个简单或者一个较难的记忆性执行，所需他们记住书信的文字内容，同时给与才会者胳膊上施以零下。进行较难执行的与才会者趋于心烦意乱时，他们才会感到较小的痛楚，通过fMRI关键技术反映出这些与才会者的神经区域内活性趋于尤其更高，fMRI往往是用来测定神经活性的转变。

Sprenger和他的同僚然后重复了测试，这次他们给与与才会者一种本品-钠洛酮（抗休克的理想本品，可以挡住类本品的现象）或者普通的麻豆注入，得出，相较只注入普通麻豆的与才会者，用作类本品拮抗剂的与才会者由于注意力分散，引起的痛楚减缓降更高了40%，因此表明介导的扮演着不可忽视作用。

历史学者的推断出了解到了心理流程可以深入地转变人们的痛楚经历，并且对于临床也有极其不可忽视的意义。历史学者指出，我们的数据分析推断出给痛楚疾病疗法提供了认知举动疗法的步骤。（生物谷：T.Shen载入）

doi:10.1016/j.cub.2012.04.006PMC:PMID:

Attention Modulates Spinal Cord Responses to Pain

Christian Sprenger1, , , Falk Eippert1, Jürgen Finsterbusch1, Ulrike Bingel1, 2, Michael Rose1, Christian Büchel1

Reduced pain perception while being distracted from pain is an everyday example of how cognitive processes can interfere with pain perception [ [1], [2], [3], [4] and [5]]. Previous neuroimaging studies showed distraction-related modulations of pain-driven activations in various cortical and subcortical brain regions [ [6], [7], [8], [9], [10] and [11]], but the precise neuronal mechanism underlying this phenomenon is unclear. Using high-resolution functional magnetic resonance imaging of the human cervical spinal cord in combination with thermal pain stimulation and a well-established working memory task [12], we demonstrate that this phenomenon relies on an inhibition of incoming pain signals in the spinal cord. Neuronal responses to painful stimulation in the dorsal horn of the corresponding spinal segment were significantly reduced under high working memory load compared to low working memory load. At the individual level, reductions of neuronal responses in the spinal cord predicted behioral pain reductions. In a subsequent behioral experiment, using the opioid antagonist naloxone in a double-blind crossover design with the same paradigm, we demonstrate a substantial contribution of endogenous opioids to this mechanism. Taken together, our results show that the reduced pain experience during mental distraction is related to a spinal process and involves opioid neurotransmission.